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| DaNa (and DaNa2.0): Nanomaterial Knowledge and Database | https://www.nanopartikel.info | https://nanopartikel.info/images/Wissensplattform-Nanomaterialien-DaNa-2-Logo.png | Germany | Karlsruhe Institute of Technology | Accessible | Aims to collect, evaluate, and present up-to-date scientific facts in an easy comprehensible manner. An interdisciplinary scientific expert team, coming from different research areas (e.g., human and environmental toxicology, biology, physics, chemistry and pharmacy), will prepare the latest research findings from the field of human and environmental nanotoxicology and present these together with material properties and possible applications for interested laymen, stakeholders and other scientists. | Provides: Standard operating procedures (SOPs) and laboratory protocols; Knowledge base addressing products and applications with nanomaterials and their potential consequences, risks, and human/environmental contact | I, K | KaRL4-6 |
| European Union Observatory for Nanomaterials | https://euon.echa.europa.eu | https://euon.echa.europa.eu/euon-theme/images/gui/bg_logo_en.png | European Union (EU) | | Accessible | contains two searchable databases: NanoData and eNanoMapper. Provides information about existing NMs on the EU market. | Provides: materials (reports, in-brief guides, and leaflets) about the regulation, safety, innovation, research, and uses of NMs in the EU | I, K | KaRL4-6 |
| eNanoMapper | http://www.enanomapper.net | | EU | | Accessible | proposes a computational infrastructure for toxicological data management of engineered nanomaterials (ENMs) to enable a more effective, integrated approach to European research in nanotechnology. It will support collaborative safety assessment for ENMs by creating an infrastructure for transparent data sharing, data analysis, and the creation of computational toxicology models for ENMs. | Provides: nanoBIO-related tools and software; datasets; learning materials (i.e., courses, papers, presentations, etc.) | D, I, K ; aims to adhere to FAIRness (Fair, Accessible, Interoperable, Re-usable) criteria | contributes to KaRL1-3 |
| NanoData Nanotechnology Knowledge base | https://nanodata.echa.europa.eu | | EU | | Accessible | | provides: data on products, research projects, publications, patents and companies, built-in charts and graphs to visualize statistics quickly. The data can be filtered by different sectors and geographic location. | I, K | KaRL1-3, contributes to KaRL5-6 |
| The Nanodatabase | http://nanodb.dk | | Denmark | The Danish Ecological Council, DTU Environment, and Danish Consumer Council | Accessible | Inventory of products containing nanomaterials. Each product has been color-coded using the NanoRiskCat framework and the methodology described in the report NanoRiskCat – A Conceptual Decision Support Tool for Nanomaterials by Hansen et al. (2011). | | D, I, K | KaRL1, contributes to KaRL5 |
| NanoEthicsBank | http://ethics.iit.edu/NanoEthicsBank/ | | United States (USA) | Center for the Study of Ethics in the Professions at IIT | Accessible | resource for researchers, scholars, students, and the general public who are interested in the social and ethical implications of nanotechnology. Provides access to nomative documents (e.g., analysis of the U.S. government's capacity for oversight and studies of the media coverage of nanotechnology), citations, and links to freely available material. | | I, K | contributes to KaRL7-9 |
| NanoHUB | https://nanohub.org/about | | United States (USA) | Center for the Study of Ethics in the Professions at IIT | Accessible | Premier place for computational nanotechnology research, education, and collaboration. Provides: | A collection of Simulation Programs for nanoscale phenomena that run in the cloud and are accessible through a web browser. Resources that help users learn about simulation programs and about nanotechnology in general. | I, K; aims to adhere to FAIRness criteria | contributes to KaRL5 and KaRL7-9 |
| NANoREG | http://www.nanoreg.eu | | Netherlands | National Institute for Public Health and the Environment | Accessible | Result of a completed EU project to develop reliable, reproducible and relevant methods for testing and assessing the effects of nanomaterials on human health and environment in a regulatory context. | Provides: Deliverables and SOPs; Experimental data, including field measurements and measurement instruments, tools, and methods; ISA-TAB nano templates; Final reports and publications | D, I, K | contribtes to KaRL 1-6 |
| Nanomaterials- Biological Interactions Knowledgebase | http://nbi.oregonstate.edu | | USA | Oregon State University and the Safer Nanomaterials and Nanomanufacturing Initiative | Accessible | a repository for annotated data on nanomaterial characterization, synthesis methods, and nanomaterial-biological interactions defined at multiple levels of biological organization. Intended to provide a framework to conduct species, route, dose and scenario extrapolations and identify key data required to predict the biological interactions of nanomaterials. | | I, K | KaRL1-3 and contribtes to KaRL4-6 |
| GoodNanoGuide | https://nanohub.org/groups/gng | | USA | National Institute for Occupational Safety and Health, Oregon Nanoscience and Microtechnologies Institute, Oregon State University; now run by NanoHUB | Accessible | goal is to create a central repository for good practices for safely handling nanomaterials that can be used and contributed to by people from all over the world. | Provides: Training resources; Occupational health and safety manual; Nomenclature and glossary; Protocols | I, K | contribtes to KaRL4-6 |
| Nano Exposure & Contextual Information Database (NECID) | http://www.perosh.eu/research-projects/perosh-projects/necid/ | | EU | Partnership for European Research in Occupational Safety and Health (PEROSH) | Accessible but not yet available | the aim of this project is to establish an information database on occupational exposure to manufactured nanoparticles to permit systematic and uniform documentation of operating, exposure, and measured data. The data is intended to be used for the purposes of research, exposure modelling, and the building of exposure scenarios to serve as a source of information for risk management and for setting occupational exposure limits. | | D, I, K | contributes to KaRL1-6 |
| Exposure Scenario Library | http://guidenano.iom-world.co.uk | | United Kingdom | MARINA, GUIDEnano, NanoReg2 | Accessible | contains descriptions of occupational and professional user scenarios for nano-objects aggregates and agglomerates (NOAA), along with the exposure measurements data. The library allows users to 'read-across' and identify similar or analogous exposure scenarios to the scenarios of interest and use their exposure information. | | D, I | contributes to KaRL5-9 |
| ISA-TAB-Nano | https://wiki.nci.nih.gov/display/ICR/ISA-TAB-Nano#ISA-TAB-Nano-title | | USA | National Institutes of Health (NIH, National Cancer Institute) | Accessible | intended to facilitate the submission and exchange of nanomaterial descriptions and characterization data (metadata and summary data) along with other files (raw/derived data files, image files, protocol documents, etc.) among individual researchers and knowledgebases. Empowers organizations to adopt standard methods for representing data in nanotechnology publications and to provide researchers with guidelines for representing nanomaterials and characterizations to achieve cross-material comparison. | | D | contributes KaRL1-3 |
| The Project on Emerging Nanotechnologies | http://www.nanotechproject.org | | USA | Woodrow Wilson International Center for Scholars | Accessible | Collaborates with researchers, government, industry, NGOs, policymakers, and others to look long term, to identify gaps in knowledge and regulatory processes, and to develop strategies for closing them. Aims to provide independent, objective knowledge and analysis that can inform critical decisions affecting the development and commercialization of nanotechnologies. | Provides inventories on: Nano-related consumer products; Environment, health, and safety research; Agriculture and food; Locations of companies, universities, government laboratories, and organizations working in nanotechnology around the US. Medicine; Silver nanotechnology in commercial products; Locations of contaminated sites utilizing some form of nanoremediation | (D, I,) K | contributes to KaRL6-9 |
| Nanotechnology Standards Database | http://nanostandards.ansi.org/tiki-index.php | | USA | American National Standards Institute | Accessible | provides information about nanotechnology standards, including published and unpublished documents | | D, I | contributes to KaRL6-9 |
| NanoCommons | https://www.nanocommons.eu | | UK | School of Geography, Earth, and Environmental Sciences, University of Birmingham | Not currently accessible | aims to create a community framework and infrastructure for reproducible science, and in particular for in silico workflows for nanomaterial safety assessment and beyond | Provides services for: Data processing and analysis (data cleansing, mining and analysis, modelling, ISA-TAB tools, ontologies); Visualization and predictive toxicity (omics, QSARs, modelling, and risk assessment tools); Online data storage and online access | (D, I,) K; aims to adhere to FAIRness criteria | contributes to KaRL6-9 with potential for KaRL 1-3 |
| NSCaT Database | https://www.srcinc.com/what-we-do/environmental/scientific-databases.html | | USA | Syracuse Research Corporation | Not accessible | a tool designed to assist in assessing the toxicity of nanoscale substances | | (D,) I | contributes to KaRL5 (a tool) |
| Nano | https://nano.nature.com | | worldwide | Springer Nature | Not accessible | Subscription literature database offering a comprehensive collection of nanomaterial data and nanoscience and nanotechnology literature references. | Provides: Summaries; Articles Patents | I, (K) | contributes to KaRL5 (a tool) |
| caNanoLab | https://cananolab.nci.nih.gov/caNanoLab/#/ | | USA | National Cancer Institute, Center for Biomedical Informatics & Information Technology | Accessible | a data sharing portal designed to facilitate information sharing across the international biomedical nanotechnology research community to expedite and validate the use of nanotechnology in biomedicine | Provides: Protocols for nanomaterial characterization assays; Results of phyico-chemical, in vitro, in vivo, and other characterizations, and associated publications; Information on nanotechnology publications, including peer-reviewed articles, reviews, and other types of reports related to the use of nanotechnology in biomedicine | D, I, K | contributes to KaRL5 (a tool) |
| Nanotechnology Characterization Laboratory | https://ncl.cancer.gov | | USA | National Cancer Institute, Division of Cancer Treatment & Diagnosis | Accessible | Performs preclinical efficacy and toxicity testing of nanoparticles and serves as a national resource and knowledge base for cancer researchers to facilitate the regulatory review of nanotechnologies intended for cancer therapies and diagnostics. | Provides:Assay cascade protocolsNanotechnology Characterization Laboratory scientific bibliography; Assay cascade protocols; Nanotechnology Characterization Laboratory scientific bibliography | D, I | contributes to KaRL5 (a tool) |
| Nano-bio database | http://nanobio.cc | | China | Hunan University, Hubei Polytechnic University, and Jiangxi Agricultural University | Accessible | Contains the properties and applications of nanomaterials, as well as mechanisms by which nanomaterials interact with organisms, proteins, cells, and nucleic acids (taken from 500 published articles). | | D, I | KaRL1-3 with potential to contribute to KaRL5 |
| NanoSafety Cluster | https://www.nanosafetycluster.eu | | EU | EU Nanosafety Cluster | Accessible | maximises the synergies between European-level projects addressing the safety of materials and technologies enabled by the use of nanoparticles. Encompasses toxicology, ecotoxicology, exposure assessment, mechanisms of interaction, risk assessment and standardisation. | Provides:publicationsorganized activities; publications; organized activities | I | Contribute to KaRL5 and KaRL7-9 |
| NanoParticle Ontology | https://bioportal.bioontology.org/ontologies/NPO | | USA | The National Center for Biomedical Ontology | Accessible | an ontology that represents the basic knowledge of physical, chemical, and functional characteristics of nanotechnology as used in cancer diagnosis and therapy. | | D | contributes to KaRL2-3 and KaRL5 (tools) |
| StatNano | https://statnano.com | | Country not provided | StatNano | Accessible | its aim is to monitor the status of nanotechnology development and policies around the world. | Provides:Data and statistics about nanotechnology products in a categorized formDatabases of events, nanomaterials, products, standards, policy documents, and universitiesPublications (available with purchase); Data and statistics about nanotechnology products in a categorized form; Databases of events, nanomaterials, products, standards, policy documents, and universities; Publications (available with purchase) | I, K | contributes to KaRL7-9 |
| NanoSafetyDB | http://nanosafetydb.com | | Iran | Iran Nanotechnology Innovation Council | Accessible | database for reliable and applicable documents in nanosafety | Provides:Documents related to nanosafety, including standards, laws and regulations, guides and procedures, policies, and strategies; Documents related to nanosafety, including standards, laws and regulations, guides and procedures, policies, and strategies | I, K | contributes to KaRL7-9 with potential for KaRL5 |
| InterNano | https://www.internano.org/internano | | USA | Center for Hierarchical Manufacturing, University of Massachusetts Amherst | Accessible | intended to support the information needs of the nanomanufacturing community by bringing together resources about the advances in applications, devices, metrology, and materials that will facilitate the commercial development and/or marketable application of nanotechnology | Provides:Reports, presentations, papers, and peer-reviewed research publications ; Reports, presentations, papers, and peer-reviewed research publications | D, I | contributes to KaRL5 |
| Nanotechnology in Our Food | http://salsa3.salsalabs.com/o/1881/p/salsa/web/common/public/content?content_item_KEY=14112#showJoin | | USA | Center for Food Safety | Accessible | an interactive database of food products containing nanomaterials | which is intended for consumers. | D, I | KaRL5 and KaRL7-9 |
| Nanowerk Nanomaterial Database | https://www.nanowerk.com/nanomaterial-database.php | | USA | Nanowerk LLC | Accessible | free tool for the nanotechnology community to research nanomaterials from more than 150 suppliers worldwide | Provides databases in the areas of:Nanomaterialsnanotechnology conferences and seminarsNanotechnology products; Nanomaterials; nanotechnology conferences and seminars; Nanotechnology products; Nanotechnology companies and laboratories; Nanotechnology applications; Publications | I | KaRL 1-3 and contributes to KaRL5 |
| ENMs Database | https://www.hsph.harvard.edu/nano/enms-database/ | | USA | Harvard School of Public Health | Not yet accessible but coming soon | an interactive database that will host the properties and characterization of the ENMs that the Center for Nanotechnology and Nanotoxicology is synthesizing and will include information on materials synthesis, properties, and characterization. | | | KaRL 1-3 and KaRL5 |
| National Toxicology Program | https://ntp.niehs.nih.gov/index.cfm | | USA | U.S. Department of Health and Human Services | Accessible | Interagency program to coordinate toxicology research and testing across the U.S. Department of Health and Human Services. Works to strengthen the science in toxicology, improve testing methods, and provide information about potentially toxic substances to government entities, scientific and medical communities, and especially the public. | Provides: -Databases and searches, -Reports and publications, -Summaries/associations | D, I, K | KaRL5 and KaRL7-9 |
| TOXNET | https://toxnet.nlm.nih.gov | | USA | U.S. National Library of Medicine | Accessible | provides a network of databases dealing with chemicals, drugs, developmental toxicity, chemical releases and mapping, genomics, household product safety, occupational exposure to chemicals, risk assessment, and animal testing alternatives | Provides information on: Human exposure, Industrial hygiene, Emergency handling procedures, Environmental fate, Regulatory requirements, Nanomaterials | I, K | KaRL1-3 |
| Hazardous Substances Data Bank | https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Provides toxicological information on potentially hazardous chemicals which has been assessed by a Scientific Review Panel. | | I, K | KaRL1-3 |
| ETHICSWEB | http://www.ethicsweb.eu/node/247 | | European Commission | European Commission, Seventh FrameworkProgramme, and cordis.europa.eu | Accessible | "ETHICSWEB is an initiative of European Ethics Documentation and Information Centres, Ethics Networks, and International Organisations to set up infrastructures on a regional and national level for the purpose of increasing transparency and interaction in the field of ethics. Contains and combines the content of multiple ethics databases from the United States and European countries including: -BELIT (Bioethics Literature Database): integrated bibliographic database of literature in the area of bioethics world wide, containing references to monographs, grey literature, legal documents, journal articles, newspaper articles, and book contributions: -Bibliography of Bioethics in Lithuania: collection of monographs and scientific articles on bioethics published by Lithuanian authors, -Biomedicina Slovenica: Slovenian national bibliographic database for the field of biomedical sciences for works which meet quality standards and bibliographic criteria, -CDE – Centre de documentation en éthique du CCNE: French national bibliographic database for the field of ethics, -EEL – Ethics Education Library: seeks to connect people interested in developing new ethics training methods and programs, to disseminate best practices and tools that have already been developed, and to foster the creation of new methods and programs for teaching students about ethical issues inherent in research and practice, -ENDEBIT – European Database on Literature of Ethics in Biotechnology: European bibliographic database on ethics of biotechnology, ETHMED – Ethics in Medicine: publications on medical ethics from over 160 journals from different academic disciplines (medicine, nursing science, health care economics, natural sciences, philosophy and theology, law, economics, and social sciences), -EUROETHICS – European database on literature of ethics in medicine, -LEWI – Bibliographic database on ethics in the sciences and humanities, -NEB – NanoEthicsBank: resource for researchers, scholars, students, and the general public who are interested in the social and ethical implications of nanotechnology, -PubMed – Bioethics subset: based on a search stratgey to facilitate searching PubMed for citations to articles in the area of bioethics, -SIBIL – Base dati di bioetica: Provides bibliographic references to literature on bioethical issues published in Italy since 1995, -GEObs – Global Ethics Observatory: System of databases with worldwide coverage in bioethics and other areas of applied ethics in science and technology, such as environmental ethics, science ethics, and technology ethics, -GEObs1 - Database 1: Who's Who in Ethics: Provides a compilation of information on ethics experts around the world who are determined via a peer review process, -GEObs2 - Database 2: Ethics Institutions: provides information on departments, institutes, centres, commissions, councils, committees, review boards, societies, associations, and other relevant entities in the area of ethics of science and technology, -GEObs3 - Database 3: Ethics Teaching Programmes: contains descriptions of existing teaching programmes within the field of ethics of science and technology, -Web resources" | | | contributes to KaRL7-9 |
| Integrated Risk Information System (IRIS) | https://toxnet.nlm.nih.gov/newtoxnet/iris.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Contains data in support of human health risk assessment, including hazard identification and dose-response assessments. | It contains descriptive and quantitative information related to human cancer and non-cancer health effects that may result from exposure to substances in the environment. | D, I, K | KaRL1-3 |
| Comparative Toxicogenomics Database | https://toxnet.nlm.nih.gov/newtoxnet/ctd.htm | | USA | U.S. National Library ofMedicine | Accessible | part of TOXNET. Provides access to scientific data describing relationships between chemicals, genes, and human diseases. | | D, I | KaRL1-3 |
| Household Products Database | https://hpd.nlm.nih.gov | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Provides information about the potential health effects of chemicals in more than 10,000 common household products | | D, I | KaRL1-3 |
| Haz-Map | https://hazmap.nlm.nih.gov | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Links Jobs and hazardous tasks with occupational diseases and their symptoms. | | D, I, K | contributes to KaRL5 |
| TOXLINE | https://toxnet.nlm.nih.gov/newtoxnet/toxline.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Bibliographic database with an assortment of citations from specialized journals and other sources. It provides references covering the biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals which are updated weekly. | | I | contributes to KaRL5 |
| Development and Reproductive Toxicology Database | https://toxnet.nlm.nih.gov/newtoxnet/dart.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Provides more than 400,000 journal references covering teratology and other aspects of developmental and reproductive toxicity which are updated weekly. | | I, K | contributes to KaRL5 |
| Carcinogenic Potency Database | https://toxnet.nlm.nih.gov/newtoxnet/cpdb.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Reports analyses of animal cancer tests used in support of cancer risk assessments for humans, including 6,540 chronic, long-term animal cancer tests from published literature, the National Cancer Institute, and the National Toxicology Program from 1980-2011. No longer updated. | | D, I, K | contributes to KaRL5 |
| Genetic Toxicology Data Bank | https://toxnet.nlm.nih.gov/newtoxnet/genetox.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Provides genetic toxicology (mutagenicity) test data from peer review of open scientific literature for more than 3,000 chemicals for the purpose of selecting assay systems for evaluation, reviewing data in the scientific literature, and recommending proper testing protocols and evaluation procedures for these systems. It covers the years 1991-1998 and is no longer updated. | | D, I | KaRL1-3 |
| OECD eChemPortal | https://www.echemportal.org/echemportal/index.action | | France | Organisation for Econoimc Co-operation and Development | Accessible | provides data submitted to government chemical review programmes at the national, regional, and international levels, including data on the physicochemical properties, environmental fate and behavior, ecotoxicity, and toxicity of different chemicals found in the environment, homes and workplaces, and in everyday products. | | D, I | KaRL1-3 |
| International Toxicity Estimates for Risk | https://toxnet.nlm.nih.gov/newtoxnet/iter.htm | | USA | U.S. National Library of Medicine | Accessible | contains data in support of human health risk assessments. It provides comparison charts of international risk assessment information and explains differences in risk values derived by different organizations | | D, I | KaRL1-3 |
| Chemical Effects in Biological Systems (CEBS) | | | USA | National Toxicology Program, U.S. Department of Health &Human Services | Accessible | contains data of interest to environmental health scientists and is designed to display data in the context of biology and study design, and permit data integration across studies for novel meta analysis | | D, I, K | KaRL1-3 |
| Aggregated Computational Toxicology Online Resource (ACToR) | https://www.epa.gov/chemical-research/actor | | USA | U.S.Environmental Protection Agency (EPA) | Accessible | a warehouse for EPA web applications which can be used to explore and visualize complex computational toxicology information. | | D, I | contributes to KaRL5 |
| Chemistry Dashboard | https://comptox.epa.gov/dashboard | | USA | U.S. EPA | Accessible | part of the ACToR database. Provides chemistry data for over 700,000 chemicals and includes chemical structures, experimental and predicted physicochemical and toxicity data. | | D, I | KaRL1-3 |
| EthxWeb | https://bioethics.georgetown.edu/explore-bioethics/online-bioethics-resources/ | | USA | | | | | | |
| Endocrine Disruption Screening Program in the 21st Century Dashboard | https://actor.epa.gov/edsp21/ | | USA | U.S. EPA | Accessible | part of the ACToR database. Provides high-throughput screening data, rapid exposure estimates, high-quality chemical structures and annotations and physchem property data used by EPA’s Endocrine Disruptor Screening Program to evaluate chemicals for endocrine-related activity. | | D, I | KaRL1-3 |
| Chemical Product Category and Exposure Databases | https://actor.epa.gov/cpcat/faces/home.xhtml | | USA | U.S. EPA | Accessible | part of the ACToR database. Provides information on which chemicals can be found in categories of products (e.g., personal care products) and observational data from exposure studies. | | I, K | KaRL1-3 |
| Downloadable Computational Toxicology Data and Models | https://www.epa.gov/chemical-research/downloadable-computational-toxicology-data | | USA | U.S. EPA | Accessible | part of the ACToR database. Provides high- throughput screening data, rapid exposure and dose, chemistry data and virtual tissues data and models. | | D, I | KaRL1-3 |
| Toxicological Profiles | https://www.atsdr.cdc.gov/toxprofiledocs/index.html | | USA | Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health &Human Services | Accessible | A compilation of toxicological information on a given hazardous substance. Each profile is peer reviewed, reflecting a comprehensive and extensive evaluation, summary, and interpretation of available toxicological and epidemiological information. | | I, K | contributes to KaRL5 |
| ATSDR Toxic Substances Portal | https://www.atsdr.cdc.gov/substances/index.asp | | USA | ATSDR, U.S. Department of Health & HumanServices | Accessible | offers toxicological resources by health effect and chemical class for community members, emergency responders, toxicological and health professionals, and health care providers. | | I, K | contributes to KaRL 5 and to KaRL7-9 |
| PubChem | https://pubchem.ncbi.nlm.nih.gov | | USA | U.S. National Library of Medicine, National Center for BiotechnologyInformation | Accessible | an open (meaning you can add your scientific data) chemistry database providing information on physicochemical properties, biological activities, patents, health, safety, and toxicity data, in addition to other types of information. | | D, I, K | KaRL1-3 |
| ChemAgora Portal | http://chemagora.jrc.ec.europa.eu/chemagora/ | | EU | European CommissionJoint Research Centre | Accessible | online portal to search for chemical information (i.e., chemical, physical, and toxicological information) from multiple databases | | D, I | KaRL1-3 |
| Contaminant Exposure and Effects- Terrestrial Vertebrates database (CEE-TV) | https://www.pwrc.usgs.gov/contaminants-online/pages/CEETV/CEETVintro.htm | | USA | U.S. Geological Survey | Accessible | contains over 18,000 records containing ecotoxicological exposure and effects information on over 460 species of terrestrial vertebrates that reside in US estuarine and coastal habitats. | | D, I | KaRL1-3 |
| Danish (Q) | | | Denmark | National Food Institute and Technical University of Denmark | Accessible | contains a repository of estimates from over 70 (Q)SAR models for 166,072 chemicals; (Q)SAR models encompass endpoints for physicochemical properties, fate, ecotoxicity, absorption, metabolism, and toxiity | | D, I | KaRL1-3 |
| Distributed Structure-Searchable Toxicity Database Network (DSSTox) | https://www.epa.gov/chemical-research/distributed-structure-searchable-toxicity-dsstox-database | | USA | U.S. EPA | Accessible | a resource for supporting improved predictive toxicology. It maps bioassay and physicochemical property data associated with chemical substances to their chemical structures, incorporating state-of-the-art cheminformatics workflows. | | D, I | KaRL1-3 and contributes to KaRL5 |
| RISCTOX | https://risctox.istas.net/en/dn_risctox_buscador.asp | | EU | European Environmental Bureau (EEB) andEuropean Trade Union Institute (ETUI) | Accessible | database of over 100,000 hazardous substances designed to provide clear, organized and concise information about health and environmental risks caused by chemicals contained in products generally used or handled by companies. | | D, I, K | KaRL1-3 |
| DrugMatrix/ToxFX | https://ntp.niehs.nih.gov/results/drugmatrix/index.html | | USA | National Toxicology Program, U.S. Department of Health and Human Services | Accessible | Databases that work together to provide one of the world’s largest toxicogenomics references (DrugMatrix) which works together with the reporting system ToxFx. These tools increase the efficiency of the toxicological assessment process. | | I, K | KaRL1-3 and contributes to KaRL5-9 |
| ECETOC Human Exposure Assessment Tools Database | https://heatdb.cremeglobal.com | | Belgium | European Centre for Ecotoxicology and Toxicology ofChemicals | Accessible | a resource for risk assessors to quickly search and locate human exposure tools and data available in the public domain, and guidance on their appropriate use using a tiering system. | | D, I, K | KaRL1-3 and contributes to KaRL5-9 |
| ECHA Information on Chemicals | https://echa.europa.eu/information-on-chemicals | | EU | European Chemicals Agency | Accessible | provides information on chemicals manufactured and imported into Europe, including hazardous properties, classification, and labelling, and information on how to use them safely | | D, I, K | contributes to KaRL5-9 |
| ECHA Use Maps Library | https://echa.europa.eu/csr-es-roadmap/use-maps/use-maps-library | | EU | European Chemicals Agency | Accessible | includes the use description and input parameters for workers exposure assessment s(SWEDs), consumer exposure assessments (SCEDs), and environmental exposure assessments (SPERCs), made available by organizations for typical uses. This information is aimed at supporting registrants with preparing chemical safety assessments (CSAs). | | D, I, K | contributes to KaRL5-9 |
| National Toxicology Program (NTP) | | | USA | National Institute of Environmental Health Sciences, National Institutes of Health | Accessible | contains a collection of databases including: Chemical Effects in Biological Systems, Data Tables for Peer Review: review the growth, survival, pathology and other toxicology data tables the underlie NTP’s draft reports, Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER): analyze, compare, and visualize multiple developmental neurotoxicity assays in an interactive web application, Historical Controls: a historical summary of the observations made on untreated or control groups from individual studies, Tox21 Toolbox: contains data-analysis tolos for accessing and visualizing Tox21 quantitative high- throughput screening 10K library data, as well as integrating with other publicly available data. | | D, I | KaRL1-3 and contributes to KaRL5-9 |
| The Carcinogenic Potency Database | https://toxnet.nlm.nih.gov/cpdb/cpdb.html | | USA | The University of California Berkley | Accessible | provides the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004 | classifies carcinogens based on mult-organ toxicity data summarized as a single record for each chemical. | D, I, K | KaRL1-3 and contributes to KaRL5-9 |
| Environmental Bioinformatics Knowledge Base (ebKB) | http://ebkb.org | | USA | Computational Chemodynamics Laboratory, Rutgers University | Accessible | evaluates, assembles, organizes, and provides information on resources that support the computational representation and analysis of environmental and biological systems and of their interactions. Resources span the fields of Cheminformatics, Enviroinformatics and Bioinformatics, as well as of Computational Toxicology, Exposure and Risk Analysis, and Pattern Recognition and Analysis. | | D, I, K | KaRL1-3 and contributes to KaRL5-9 |
| Toxicity Forecaster (ToxCast) | | | USA | U.S. EPA | Accessible | part of the ACToR database. Provides high- throughput screening data on over 9,000 chemicals and information on approximately 1,000 assay endpoints. | | D | KaRL1-3 and contributes to KaRL5-9 |
| Comparative Toxicogenomics Database | http://ctdbase.org | | USA | NC State University | Accessible | integrates data from curated scientific literature to describe chemical interactions with genes and proteins, and associations between diseases and chemicals, and diseases and genes/proteins | contains over 15 million toxicogenomic relationships. | D, I, K | KaRL1-3 and contributes to KaRL5-9 |
| The Toxin and Toxin Target Database (T3DB; soon to be known as the Toxic Exposome Database) | http://www.t3db.ca | | Canada | The Metabolomics Innovation Centre, Canadian Institutes of Health, andCanada Foundation for Innovation | Accessible | bioinformatics resource that combines toxin data with toxin target information. The database currently houses 3,678 toxins described by 41, 602 synonyms, including pollutants, pesticides, drugs, and food toxins, which are linked to 2,073 toxin target records. | | D, I, K | KaRL1-3 and contributes to KaRL5-9 |
| Cefic Long-Range research Initiative (LRI) | | | Belgium | The European ChemicalIndustry Council | | A compilation of databases relating to human health, including: -RepDose – relational database on subacute to chronic toxicity (must request access), -MOD-Finder: Multi-Omics Dataset Finder (accessible: https://webapp.ufz.de/mod_finder/) Level of data: D, I, -DTOX – DIAMONDS' Toxicity Toolbox: Demonstrating chemical, physical, and toxicological properties for a compound and its structural or biological analogues (not yet released), -ECEL 3.0 – Integrated Risk Management Measure Library (not yet released) | | | KaRL1-3 and contributes to KaRL5-9 |
| Global Digital Library on Ethics | https://www.globethics.net/about-us/portrait | | Switzerland | globethics.net | Accessible | provides an electronic platform for ethical refection and action for people all over the world. | | I, K | contributes to KaRL7-9 |
| Cefic Long-Range research Initiative (LRI) | | | Belgium | The European Chemical Industry Council | | A compilation of environmental models and tools including: -Atmospheric DEPosition and Transport model (ADEPT): modeling deposition fluxes in Europe (accessible by download) Level of data: D, I -AMBIT – Cheminformatics data management system: facilitating chemical safety assessment (accessible: https://ambitlri.ideaconsult.net/tool2) Level of data: D, I -ART – Advanced REACH Tool: estimating inhalation exposure with your own data (accessible: https://www.advancedreachtool.com) Level of data: D, I -BCF – Bioconcentration Factor Database: deriving bioconcentration factor values (available: http://ambit.sourceforge.net/euras/) Level of data: D, I -BiotS – Biotransformation Susceptibility software: Assessing biotransformation susceptibility of chemicals (accessible: http://cefic-lri.org/toolbox/biots/) Level of data: D, I -Busy – Bayesian Uncertainty System (available: http://busymath.googlepages.com) Level of data: D, I -CEMAS – Chemical Exposure Management and Assessment System: Capturing chemical exposure and risk assessment data (unavailable: no longer compatible with current operating systems) -FeDTex – Fertility and Developmental Toxicity in Experimental Animals (accessible by request) -GEMCO – Generic Estuary Model for Contaminants: calculating the environmental concentrations of contaminants in an estuary, food web uptake, and fluxes from estuaries to open waters (accessible by download: http://cefic-lri.org/toolbox/gemco/) Level of data: D, I -GREAT-ER – Geography-referenced Regional Exposure Assessment Tool for European Rivers: environmental risk assessment and management of chemicals in river basins (available for free to anyone involved in environmental research, risk assessment, management or education) -IndusChemFate – Generic physiologically-based toxicokinetic tool: estimating the level of a chemical in various body tissues and body fluids following exposure (accessible by download: http://cefic- lri.org/toolbox/induschemfate/) -OLYMPIC CRAFT – chemical reactivity and fate (accessible by download: http://www.molecular- networks.com/products/craft) -MEGen – Model Equation Generator: generating and analyzing PBPK models (accessible by download: http://xnet.hsl.gov.uk/megen/) -RepDose – Relational database on subacute to chronic toxicity: performing analyses on repeated dose toxicity (must request access) -TERRACE – Terrestrial Runoff Modelling for Risk Assessment of Chemical Exposure: predicting chemical concentrations of chemicals in waters entering river systems (not accessible; no longer compatible with current operating systems) -HBM Simulator – Human Biomonitoring Simulator: investigating the representativeness of spot biomonitoring samples (accessible by download: http://cefic-lri.org/toolbox/hbm-simulator/) Level of data: D, I -INTEGRA – Integrated External and Internal Exposure Modelling Platform: Assessing the source-to-dose continuum for the entire life cycle of chemical substances (accessible: www.integra.cperi.certh.gr) Level of data: D, I -BAT-Bioaccumulation Assessment Tool: a quantitative weight of evidence framework to aid bioaccumulation assessment (accessible by download: http://cefic- lri.org/toolbox/bioaccumulation-assessment-tool-bat-a- quantitative-weight-of-evidence-qwoe-framework-to-aid- bioaccumulation-assessment/) Level of data: D, I -MOD-Finder: Multi-Omics Dataset Finder (accessible: https://webapp.ufz.de/mod_finder/) Level of data: D, I -DustEx – Human exposure to chemical substances via house dust: estimating human exposure to substances released from products and articles in the outdoor environment (accessible: https://dustex.nl/) Level of data: D, I -GUTS – General Unified Threshold model of Survival: modeling survival of organisms through time under time- variable exposure to chemicals (will be released in December 2019) -R-Vis – Open access PBPK modeling platform: modeling biologically based, quantitative safety and risk assessment of chemicals (not accessible; not yet released) -DTOX – DIAMONDS’ Toxicity Toolbox: demonstrating chemical, physical and toxicological properties for a compound and its structural or biological analogues (will be released in July 2019) -ECEL 3.0 – Integrated Risk Management Measure Library (not yet released) | | | contributes to KaRL5 |
| Chemical Carcinogenesis Research Information System | https://toxnet.nlm.nih.gov/newtoxnet/ccris.htm | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Contains chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primary journals, current awareness tools, NCI reports, and other sources from 1985-2011. No longer updated. | | D | KaRL1-3 and contributes to KaRL5-9 |
| Collaborative on Health and the Environment (CHE) | | | USA | CHE | Accessible | summarizes links between chemical contaminants and approximately 180 human diseases or conditions | | I, K | contributes to KaRL5-9 |
| ECOTOXicology knowledgebase | https://cfpub.epa.gov/ecotox/ | | USA | U.S. EPA | Accessible | comprehensive, publicly available knowledgebase providing single chemical environmental toxicity data on aquatic life, terrestrial plants, and wildlife obtained predominantly from peer-reviewed literature | | D, I | KaRL1-3 and contributes to KaRL5-9 |
| Endocrine Active Substances Information System (EASIS) | https://ec.europa.eu/jrc/en/scientific-tool/endocrine-active-substances-information-system-easis | | EU | European Commission ScienceHub | Accessible | contains information on chemicals with the potential to interact with the endocrine system for over 500 chemicals derived from approximately 9000 studies that cover both in vitro and in vivo assays in different species | | D, I | KaRL1-3 and contributes to KaRL5-9 |
| Endocrine Disruptor Knowledge Base | https://www.fda.gov/science-research/endocrine-disruptor-knowledge-base/accessing-edkb-database | | USA | U.S. Food and Drug Administration | Accessible | "resource for research and regulatory scientists to foster the development of computational predictive toxicology models and reduce dependency on animal experiments. |
| Provides: -a biological activity database, (Q)SAR training sets, -in vitro and in vivo experimental data for more than 3,000 chemicals, -literature citations, -chemical-structure search capabilities." | | D, I | contributes to KaRL5-9 |
| Chemical Lists Information System (CheLIST) | http://chelist.jrc.ec.europa.eu | | EU | European Commission, Joint Research Centre | Accessible | provides a means of identifying whether a chemical (or chemical group) has been used in a research or validation project and whether the chemical of interest is regulated and listed under a specific regulatory inventory | | D, I | contributes to KaRL5 |
| Environmental Health and Safety freeware | http://www.ehsfreeware.com | | USA | Donley Technology | Accessible | Provides links to free data and software dealing with environmental health and safety, including sustainability, environmental healthy and safety training, compliance and reporting, databases and electronic publications, risk analysis and emergency reponse, investigation and environmental remediation, and environmental health and safety design, operation, and maintenance. | | D, I | contributes to KaRL5 |
| EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Positive Chemicals | https://ec.europa.eu/jrc/en/scientific-tool/eurl-ecvam-genotoxicity-and-carcinogenicity-consolidated-database-ames-positive-chemicals | | EU | European Commission | Accessible | contains genotoxicity and carcinogenicity data for 726 Ames positive chemicals compiled from a variety of sources which are intended to aid in the development and evaluation of alternative approaches to animal testing | | D, I | KaRL1-3 |
| EU Reference Laboratory ECVAM KinParDB (ECVAM Kinetic Parameters DataBase) | | | EU | European Commission JointResearch Centre | Accessible | a pilot database of toxicokinetic parameters of compounds used as reference substances in various in vitro toxicity testing programs | | D, I | contributes to KaRL3-4 |
| International Programme on Chemical Safety (IPCS INCHEM) | http://www.inchem.org | | Canada | World Health Organization, Canadian Centre for Occupational Health and Safety | Accessible | public, searchable, peer-reviewed chemical safety- related publications and database records from international bodies, including Concise International Chemical Assessment Documents (CICADS), International Chemical Safety Cards (ICSCs), Pesticide Data Sheets (PDSs), Screening Information Data Sets (SIDS) for High Production Volume Chemicals, among others | | I, K | KaRL1 and contributes to KaRL5-9 |
| Interspecies Database | https://www.interspeciesinfo.com | | The Netherlands | Utrecht University | Accessible | researchers make an optimal choice of the species and strain of the animal model to maximize efficient extrapolation of animal data to humans and other animals. | | I, K | contributes to KaRL3-4 |
| Alternatives to Animal Testing | https://toxnet.nlm.nih.gov/altbib.html | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. Provides citations from articles, books, book chapters, and technical reports on alternatives to the use of live vertebrates in biomedical research and testing from 1980-2000. No longer updated. | | I, K | contributes to KaRL3-4 |
| ISSTOX Chemical Toxicity Databases | http://old.iss.it/meca/index.php?lang=1&anno=2013&tipo=25 | | Italy | Istituto Superiore di Sanita | Accessible | Contains databases for structure-activity relationship studies for toxicity production, including long-term carcinogenicity bioassays on rodents (ISSCAN), in vitro Mutagenesis in Salmonella typhimurium (Ames test) (ISSSTY), and in vivo Mutagenesis (micronucleus test) (ISSMIC) | | I, K | KaRL1-3 |
| TOXMAP(https://toxmap.nlm.nih.gov/toxmap/) | https://toxmap.nlm.nih.gov/toxmap/ | | USA | U.S. National Library of Medicine | Accessible | part of TOXNET. A Geographic Information System (GIS) that uses maps from the U.S. to help users visually explore environmental health data from the U.S. Environmental Protection Agency’s (EPA’s) Toxics Release Inventory (TRI) and Superfund Program, as well as several non-EPA datasets. | | D, I | contributes to KaRL5-9 |
| Toxics Release Inventory | https://toxnet.nlm.nih.gov/newtoxnet/tri.htm | | USA | U.S. National Library ofMedicine | Accessible | part of TOXNET. Provides annual environmental release information for over 600 toxic chemicals by U.S. facilities. | | D, I | contributes to KaRL5-9 |
| Human and Environmental Risk Assessments | https://www.heraproject.com/RiskAssessment.cfm | | Belgium | HERA | Accessible | Provides toxicity and risk data on ingredients found in household cleaning products | | I | KaRL1-3 and contributes to KaRL5-9 |
| EDCs Databank | https://edcs.unicartagena.edu.co | | Colombia | Universidad de Cartagena, Colciencias Colombia, Environmentaland Computational Chemistry Group | Accessible | provides a 3D-structure database of endocrine disrupting chemicals | | D, I | KaRL1 |
| ECHA Classification & Labelling Inventory Database | https://echa.europa.eu/information-on-chemicals/cl-inventory-database | | EU | European Chemicals Agency | Accessible | provides classification and labeling information on notified and registered substances received from manufacturers and importers; includes the list of harmonized classifications. | | D, I | contributes to KaRL5 |
| Hazardous Substances Information System | http://hcis.safeworkaustralia.gov.au | | Australia | Safe Work Australia | Accessible | internet advisory service that assists you in finding information on substances that have been classified in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) by an authoritative source, such as ECHA or the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) | | D, I | contributes to KaRL7-9 |
| Hazardous Chemical Information System | http://hcis.safeworkaustralia.gov.au | | Australia | Safe Work Australia | Accessible | internet advisory service that assists you in finding information on chemicals that have been classified in accordance with the GHS by an authoritative source, such as ECHA or the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) | | D, I | contributes to KaRL7-9 |
| ToxChem: Toxic Chemicals Database | http://iitrindia.org/envis/Default1.aspx | | India | ENVIS Centre Distributed Information Dentre (DIC) on Toxic Chemicals, Indian Institute of Toxicology Research | Accessible | provides information on chemical under different attributes: their uses, properties, symptoms of exposure, antidotes, treatment, toxicity data, health risks, hazards to humans and the environment, precautions, prevention, storage, and disposal. Intended for scientists, research workers, regulatory agencies, policy planners, and other users. | | D, I | contributes to KaRL5-9 |
| Japan Existing Chemical Database (JECDB) | http://dra4.nihs.go.jp/mhlw_data/jsp/SearchPageENG.jsp | | Japan | ChemicalsInvestigation Promoting Council, Japan | Accessible, but nearly all documents are in Japanese | database of results of toxicity screening tests for both Japan’s existing chemicals safety programme and the OECD HPV chemicals programme. | | I, K | KaRL1-3 |
| JRC (Q) | | | EU | European Commission Joint ResearchCentre | Accessible | provides information on the validity of QSAR models that have been submitted to JRC’s EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), which is intended to help identify valid QSARs, e.g., for the purposes of REACH | | D, I | contributes to KaRL5 |
| National Pesticide Information Center | http://npic.orst.edu/ingred/aifact.html | | USA | National Pesticide InformationCenter, Oregon State University | Accessible | provides active ingredient fact sheets intended for the general public summarizing the current knowledge for different pesticide ingredients. | | I, K | contributes to KaRL5 |
| National Center for Toxicological Research Liver Cancer Database (NCTRLcdb) | https://www.fda.gov/science-research/bioinformatics-tools/nctr-liver-cancer-database-nctrlcdb | | USA | U.S.Food and Drug Administration | Accessible | was constructed with the assumption that organ- specific carcinogenicity is a cleaner endpoint for building a biological predictive model; contains 999 chemicals based on liver-specific carcinogenicity | | D, I, K | contributes to KaRL4 |
| Ethical Consumer | https://www.ethicalconsumer.org | | UK | Ethical Consumer | Partly accessible | provides the tools and resources needed to make everyday shopping choices simple, informed, and ethical, offering detailed research of over 40,000 companies, brands, and products. | | | contributes to KaRL5-9 |
| Environmental Working Group’s(EWG’s) | | | USA | EWG | Accessible | online profiles for cosmetics and personal care products are provided along with their potential hazards and health concerns. The aim is to fill in where industry and government leave off. EWG’s staff scientists compare the ingredients on personal care product labels and websites to information in nearly 60 toxicity and regulatory databases, providing easy-to-navigate ratings for a wide range of products and ingredients on the market. | | D, I, K | contributes to KaRL5-9 |
| Openfoodtox | https://www.efsa.europa.eu/en/press/news/180719 | | EU | European Food Safety Authority | Accessible | provides open source data for substance characterization, links to EFSA's related output, background European legislation, and a summary of critical toxicological endpoints and reference values. Intended for scientific advisory bodies and stakeholders with an interest in chemical risk assessment. | | I, K | contributes to KaRL5-9 |
| Pesticide Action Network (PAN) | | | NorthAmerica | PAN | Accessible | provides current toxicity and regulatory information for pesticides. | | I, K | contributes to KaRL5 |
| Proposition 65 Warnings | https://www.p65warnings.ca.gov | | USA (California) | California Office of Environmental Health Hazard Assessment (OEHHA) | Accessible | provides the public with information on chemicals, products, and locations often associated with Proposition 65 warnings, which inform Californians about their exposures to chemicals that cause cancer, birth defects, or other reproductive harm. | | I, K | contributes to KaRL5-9 |
| Cleaning Product Ingredient Safety Initiative | https://www.cleaninginstitute.org/industry-priorities/science/cleaning-product-ingredient-safety-initiative | | USA | American Cleaning Institute | Accessible | a resource for accessing and understanding information related to the safety of ingredients used in household cleaning products. Provides: -searchable inventory of ingredients in U.S. household cleaning products, -exposure information for each ingredient within each product category in which it is used, -hazard information for each ingredient, -no-effect values derived from regulatory benchmarks, published assessments, or available hazard data for oral, dermal, and inhalation exposure pathways | | D, I, K | contributes to KaRL5-9 |
| Acute Toxicity Database | https://www.cerc.usgs.gov/data/acute/acute.html | | USA | U.S. GeologicalSurvey (USGS) | Accessible | provides result summaries from aquatic acute toxicity tests conducted by USGS. | | D, I | contributes to KaRL5-9 |
| Toxic Substances Control Act (TSCA) | | | USA | U.S. EPA | Accessible | contains all existing chemical substances manufactured, processed, or imported in the U.S. that do not qualify for an exemption or an exclusion under TSCA. | | D, I | contributes to KaRL8-9 |
| ChemIDplus | https://chem.nlm.nih.gov/chemidplus/chemidlite.jsp | | USA | U.S. NationalLibrary of Medicine | Accessible | part of TOXNET. A dictionary of over 400,000 chemicals (names, synonyms, and structures). | | D | KaRL1 |
| Leadscope, Inc. Toxicity Databases | http://www.leadscope.com/toxicity_databases/ | | Japan | CTC Life Science Corporation | Not accessible except by payment | provides three databases: -Leadscope Toxicity Database: Nearly 180,000 chemical records with over 400,000 toxicity studies from literature sources, -SAR Carcinogenicity Database: High quality carcinogenicity database with validated structures to be used as a resource for preparing training sets, -SAR Genetox Database: high quality genetic toxicity database to be used as a resource for developing predictive modeling training sets. | | | KaRL1 |
| RTECS: The Registry of Toxic Effects of Chemical Substances | https://www.cdc.gov/niosh/docs/97-119/default.html | | USA | Centers for Disease Control and Prevention (CDC) | Not accessible except by payment | provides a compendium of chemical data extracted from the open scientific literature, including various types of toxicity data (primary irritation, mutagenic effects, reproductive effects, tumorigenic effects, acute toxicity, and other multiple dose toxicities). | | | KaRL1 |
| Syracuse Research Corporation (SRC) | | | USA | SRC | Not accessible except by payment | provides a variety of chemical, environmental, and toxicological databases that support the development of new methodologies to enhance hazard and exposure assessments. These include: -Environmental Fate Data Base (EFDB): provides bibliographic information and experimental value data to construct structure-activity correlations for degradability and transport of chemicals in the environment, -PHYSPROP Database: contains chemical structures, names, and physical properties foro ver 41,000 chemicals, -Database of SMILES Notations: contains about 103,000 structures of chemicals used in commerce, -TSCATS database: central system for collection, maintenance, and dissemination of information on unpublished technical reports submitted by industry to the UPA under Toxic Substances Control Act (TSCA), -TSCA 8(e)/FYE Initial Data Screen Database: stores screening information derived from 8€ and FYE submissions, -TRI-CHIPs Database: contains toxicity information from multiple data sources on chemicals included in the Toxics Release Inventory (TRI) list, -Response Status Database: designed to help the EPA track activities under the High Production Volume Challenge Program; presents information on physicochemical, environmental fate, health, and ecotoxicity endpoints, -Endocrine Disruptor Priority Setting Database: produced for the Endocrine Disruptor Screening and Testing Advisory Committee Program at the EPA, -NSCaT Database: a tool designed to assist in assessing the toxicity of nanoscale substances | | | KaRL1 |
| Toxygates | https://omictools.com/toxygates-tool | | France | omicX | Not accessible except by payment | an integrated platform for toxicogenomics data anslysis. Users can integrate transcriptome's response to particular compounds/conditions to explore toxicity mechanisms for data within the Japanese Toxicogenomics Project Database, which contains systematically collected microarray samples from rats and primary human hepatocytes after exposure to 170 different compounds at different dosages and time intervals. | | | KaRL1 |
| ChemTunes | https://www.mn-am.com/products/chemtunestoxgps | | Germany | Molecular Networks GmbH – Computerchemie, Altamira LLC | Not accessible except by payment | a cheminformatics platform and expert quality controlled database to store, manage, search, and retrieve chemical substances along with their in vitro and in vivo toxicity, safety evaluation, and metabolism data, designed to facilitate and support the safety and risk assessment process for approximately 100,000 chemical compounds. | | | KaRL1 |
| ToxGPS | https://www.mn-am.com/products/chemtunestoxgps | | Germany | Molecular Networks GmbH – Computerchemie, Altamira LLC | Not accessible except by payment | provides a reliable toxicity knowledgebase including workflows and predictions for a series of in vivo and in vitro human health and regulatory-relevant endpoints. | | | KaRL1 and contributes to KaRL5-9 |
| RiskIE: Risk Information Exchange | https://www.tera.org/Alliance%20for%20Risk/RiskIE.htm | | USA | Alliance for Risk Assessment (ARA), ToxicologyExcellence for Risk Assessment (TERA) | Accessible | database of risk assessments that are in progress around the world | | D | KaRL1 and contributes to KaRL5-9 |
